Indiana's tech ecosystem is hitting its stride with a combination of serious infrastructure investment and Midwestern practicality. Indianapolis leads the charge with its 50-acre 16 Tech Innovation District, where the signature bridge opened in spring 2025 to connect entrepreneurs, researchers, and students directly to the city's research and medical corridor.
Meanwhile, IU's $138 million Launch Accelerator for Biosciences is breaking ground, signaling the state's commitment to bioscience innovation. But the momentum extends beyond the capital — Carmel and Zionsville are home to thriving product engineering firms and environmental tech companies, while the collaborative spirit that defines the Hoosier state shows up in incubators like High Alpha and Elevate Origins.
Whether you're drawn to healthtech, SaaS, nonprofit tech, or environmental solutions, Indiana offers real growth opportunities without the coastal price tag or pressure.
Olio connects the fragmented world of post-acute care. Their collaboration platform links rehab facilities, home health agencies, and skilled nursing — bringing coordination to a sector that desperately needs it. When providers can communicate effectively and share information seamlessly, patients experience better outcomes and fewer preventable complications.
As a fast-growing, Series B-funded company managing 450,000+ attributed lives, Olio offers the opportunity to shape both product and culture from the ground up. The team emphasizes collaboration, grit, and having fun at work — bonding over axe throwing and post-work hangouts alongside building software that healthcare providers actually use and love. With generous PTO, performance-based rewards, and hybrid flexibility, they're working on infrastructure problems in healthcare that have been overlooked for too long, backed by measurable impact: clients are seeing 50% reductions in readmissions and significant cost savings.
OneCause has enabled more than $5 billion in charitable giving through its fundraising software built specifically for nonprofits. Their platform powers everything from in-person galas to virtual auctions to year-round campaigns, giving organizations the flexibility they need as donor behavior evolves. What sets them apart is the understanding that fundraising is about building lasting relationships between nonprofits and their supporters.
Recognized by the Indiana Chamber of Commerce as a Best Place to Work in Indiana and named to Inc. Magazine's Best Workplaces list for two consecutive years, OneCause combines mission-first culture with genuine innovation. The team operates in a hybrid environment with some roles requiring 2-3 days onsite, and offers benefits like three paid volunteer days and the ability to gift OneCause software to a nonprofit of their choice each year. They're also deeply connected to the nonprofit community they serve. With open roles across the company, OneCause is a place where you can build technology that directly fuels social good while working alongside people who genuinely care about the impact.
Bloomerang addresses one of the biggest challenges nonprofits face: donor retention. Their CRM is purpose-built for the nonprofit sector, addressing pain points around donor engagement and relationship management — problems that have a massive downstream impact when solved well. Unlike generic CRMs that force nonprofits to adapt, Bloomerang’s software understands their workflows, so the product gets used and drives results.
The company's remote-hybrid setup with an Indianapolis headquarters offers flexibility, while benefits and wellbeing programs signal that they take care of their team as seriously as they serve their customers. Bloomerang has built a culture where people stay. They understand that employee retention and donor retention aren't that different. If you want to work somewhere that lives its values while building technology the nonprofit sector desperately needs, this is it.
Zylo tackles SaaS sprawl head-on. Their platform brings visibility and control to IT teams trying to manage increasingly complex software ecosystems by tracking subscriptions, optimizing licenses, and uncovering redundancies that waste money and create security risks.
Based in Indianapolis with hybrid work options, Zylo emphasizes professional growth and customer trust as core values. The team is solving a problem that's both technical and business-critical, which means the work requires both sharp thinking and strong relationships. With open roles across product, customer success, and sales, Zylo is a place where you can make an impact on how enterprise organizations manage their software investments.
OnBoard helps leadership teams make better decisions through better governance. Trusted by mission-driven organizations and businesses around the world, their platform brings structure and transparency to board management, handling everything from secure document sharing and meeting workflows to voting and approvals.
With roots in Lafayette and a presence in Indianapolis, OnBoard offers remote-hybrid roles and has earned recognition through multiple industry awards including Stevie Awards and G2's top rankings for board management software. They're growing in a space where demand for strong governance is accelerating across every sector — from nonprofits to healthcare to public companies facing increased scrutiny.
Authenticx uses conversation intelligence to help healthcare organizations understand patient experiences at scale. By analyzing conversations between patients and providers, they surface insights that drive better outcomes and more empathetic care, turning qualitative data into actionable intelligence.
Recognized by Powderkeg for its emerging culture and honored by Techpoint and Indianapolis Business Journal, Authenticx has built a reputation as a best place to work through its focus on teamwork, authenticity, and genuine work-life balance. Based in Indianapolis with hybrid and remote options, the company offers unlimited PTO, no-cost medical insurance, and mental health support—benefits that feel intentional given their healthcare focus. The team includes people who understand both the technical challenges of conversation AI and the human stakes of healthcare delivery. As patient experience becomes a bigger focus for healthcare organizations, Authenticx is positioned at the intersection of urgent need and emerging capability.
15Five builds employee engagement software that actually practices what it preaches. With Indianapolis roots, they operate remote-first with a hub in the city. Their platform helps managers and teams have better conversations, set meaningful goals, and build cultures where people actually want to work. The product focuses on continuous feedback and performance management, but the real value is in helping distributed teams stay connected and aligned.
What makes 15Five interesting is how seriously they take their own product — they've built a "High-five culture" internally that emphasizes mental health benefits and comprehensive DEI programs. They're a mid-sized company solving the perennial challenge of keeping distributed teams engaged, which has only become more critical as remote work solidifies.
Salesforce brings global scale and Midwest roots together at its Indianapolis tower. The Ohana culture (Hawaiian for family) that Salesforce is known for translates to strong support systems, extensive career development resources, and a genuine commitment to giving back. Employees receive seven paid volunteer days annually and up to $10,000 in matching gifts, while the 47th-floor 'Ohana Floor' — accommodating up to 300 guests — is offered free to nonprofits for fundraising events and receptions.
Most roles follow an office-flex model requiring three days per week in the office, with the sheer volume of open positions meaning opportunities across functions, from engineering and product to sales and customer success. For those who want the resources and stability of a large company without relocating to a coast, Salesforce's Indianapolis office provides a compelling option. The company's focus on corporate social responsibility is particularly visible in its local operations, where partnerships with organizations like United Way of Central Indiana and Booth Tarkington Civic Theatre demonstrate real community investment beyond check-writing.
Resultant is a digital product studio that offers variety for those who like it in their technical work. Operating within a larger consultancy, they focus on building custom software solutions for clients across industries. Their builder culture emphasizes craftsmanship and creativity, giving their team exposure to a wide range of technical challenges — from greenfield projects to legacy system modernization.
Recognized as a 2024 Top Workplace with a Work-Life Flexibility Award by Top Workplaces and ranked #1 for hybrid work among Best Places to Work in IT, Resultant has built a culture where 91% of employees agree the organization operates by strong values. The firm offers self-managed PTO, a career pathways program that prioritizes breadth of experience over traditional ladder-climbing, and maintains an active commitment to DEI. Working in a consultancy model means you're constantly learning new domains and problem spaces, helping to accelerate your growth as an engineer or designer, all while being supported by mentorship and professional development that's baked into how they operate.
ShipSigma helps companies optimize a massive line item most overlook: shipping costs. Their parcel spend analytics platform helps companies understand and optimize their shipping expenses — uncovering overcharges, identifying savings opportunities, and bringing data-driven clarity to carrier negotiations. In an e-commerce world where margins are tight and shipping expectations are high, the platform delivers real value through insights that directly improve the bottom line.
Named to Inc. Magazine's Best Workplaces 2023 (one of only four Indiana companies recognized) and a multi-year Inc. 5000 honoree, ShipSigma has built a culture centered on transparency, remote work flexibility, and open access to leadership. Based in downtown Indianapolis, they offer complete visibility into company revenue and strategy while empowering employees to make decisions driven by core values. Small enough that individual contributions move the needle quickly, they're in rapid growth mode, planning to add 125 employees by 2026 and managing $1B+ in parcel spend for 300+ customers who've saved over $100M since 2018.
T2 Systems builds the infrastructure behind parking systems with software that helps universities, municipalities, and enterprises manage everything from permits to enforcement to payment processing. Trusted by close to 400 organizations across the U.S. and Canada, they've earned recognition as a past TechPoint MIRA Award winner and appeared on the Fortune 5000 list for seven consecutive years.
T2 offers the resources and stability of a mid-sized company with a clear mission around improving mobility operations. Employees in Indianapolis rate the work-life balance highly, and the team is purpose-driven and focused on building reliable systems for complex environments where uptime matters and user experience affects thousands of people daily. With virtual offices throughout the U.S. and Canada, they provide flexibility alongside the structure of an established player in a niche but essential space.
SEP is a product engineering firm where high-trust, low-ego teamwork is built into how they operate. They work on complex engineering challenges across industries, giving their team exposure to diverse technical problems and the chance to build products from concept to launch. Whether it's medical devices, industrial systems, or consumer products, SEP's engineers get to solve real problems that matter.
What sets SEP apart is its culture. The company offers profit sharing, emphasizes inclusive collaboration, and creates space for engineers to do their best work. It's a hybrid environment where people genuinely seem to enjoy what they're building and who they're building it with. The company invests in craftsmanship and continuous learning, treating engineering as both a technical discipline and creative practice.
Zotec Partners tackles the notoriously complex world of medical billing. Its revenue cycle technology helps healthcare organizations navigate the labyrinth of medical billing and collections — handling everything from claims processing to denial management to patient payments. When healthcare providers can get paid accurately and efficiently, they have more resources to focus on patient care, which is where the real impact shows up.
Named Best Places to Work in Indiana three consecutive years (2020-2022) and recognized in six categories of the 2022 Powderkeg Unvalley Awards, Zotec has built a culture that employees consistently vouch for. Located in Carmel with hybrid and in-person roles, the company offers volunteer time off through The Zotec Effect program (with charitable giving matches up to $200), hasn't raised health insurance premiums in over a decade, and provides professional development support. As the country's largest privately-held provider supporting 120+ million medical encounters annually, they're growing in a healthcare tech space that shows no signs of slowing down.
120Water simplifies the complex challenge of managing water testing programs across utilities, schools, and organizations. The platform tackles compliance, sample tracking, and data management for water programs, helping communities avoid the kind of water crises that make headlines — impact that's both measurable and critical.
Founded in 2016 in Zionsville and recognized as the fastest-growing digital water company in the country, 120Water has raised significant funding (including a $7M Series A) and serves customers in over 30 states. Located in Zionsville with hybrid flexibility, they've built a mission-driven culture led by CEO Megan Glover, named Indiana Chamber's 2021 Dynamic Leader of the Year. They're small enough that your contributions matter from day one, and they're working in a space where regulatory requirements around water safety continue to increase nationwide, meaning the work directly protects public health.