Top Tech Companies in Wisconsin to Watch in 2026

Wisconsin’s innovation ecosystem is thriving. From precision medicine to advanced manufacturing, we rounded up companies redefining what it means to build with purpose. Each combines technology, talent, and impact to drive progress in healthcare, clean energy, finance, and industry. 

Here’s a look at the organizations shaping the state’s next era of growth. 

Top Companies to Watch in Madison

Promega

Promega develops tools and technologies for life-science research, drug discovery, and molecular diagnostics. The company recently expanded its ultra-low-temperature manufacturing capacity, partnered with Addgene on a global plasmid collection, and deepened its sustainability work through the Science-Based Targets initiative. These investments show Promega’s long-term view of science — building infrastructure and partnerships that help researchers tackle some of the world’s toughest biological questions.

SHINE Technologies

SHINE Technologies engineers fusion-based systems that produce medical isotopes and advanced materials. The company recently acquired Lantheus’ SPECT business, gained key imaging assets, and built on prior multi-million-dollar funding for isotope production. These milestones move SHINE closer to commercial fusion applications that could transform nuclear medicine and strengthen domestic supply chains.

Epic Systems

Epic Systems builds electronic health-record software used by hospitals and health networks worldwide. In 2025, Epic upgraded its Cosmos data platform, which now connects more than 250 million patient records, and expanded its cloud interoperability suite. These updates extend Epic’s influence beyond data storage by turning vast health information into insights that improve care quality and population health.

Exact Sciences

Exact Sciences develops molecular diagnostics that enable earlier cancer detection, including its Cologuard and Oncotype DX tests. The company released promising 2025 data for its multi-cancer early detection pipeline and expanded manufacturing to support upcoming clinical trials. Its commitment to accessible, evidence-driven screening continues to shape preventive care.

Fetch

Fetch operates a mobile app that transforms receipts into rewards and data-driven insights for brands. In 2025, it secured major financing from Morgan Stanley and General Catalyst and launched Fetch Ads+ to expand into retail media. These moves signal Fetch’s shift from loyalty platform to full-scale marketing engine, helping brands and consumers build smarter, more rewarding relationships.

Elephas

Elephas applies live-cell imaging and AI to predict how individual tumors respond to therapy, giving oncologists faster, more accurate treatment guidance. In 2025, it expanded its Madison lab network and partnered with top cancer centers to validate its technology. By combining scientific precision with patient impact, Elephas is turning personalized oncology from concept into clinical reality.

Redox

Redox connects healthcare systems, payers, and digital-health apps through a unified data-integration platform. This year, it entered new European markets and earned additional certifications with major EHR vendors, making secure data exchange more accessible. Redox continues to set the standard for healthcare interoperability.

Understory

Understory builds ground-level weather sensors that generate data for insurers, farmers, and climate-risk analysts. The company launched a new sensor suite in 2025 and signed a long-term licensing deal with a national reinsurer. Its precise climate analytics help businesses better price risk and adapt to increasingly volatile weather conditions.

Moxe Health

Moxe Health improves healthcare data exchange through secure APIs that connect payers and providers. The company’s 2025 acquisition of a data analytics firm enhanced its ability to standardize and share clinical information at scale. By simplifying complex data workflows, Moxe is helping health organizations deliver smarter, faster care.

FluGen

FluGen develops next-generation vaccines for influenza and respiratory viruses using its proprietary M2SR platform. In 2025, the company advanced its universal flu candidate into Phase 2 clinical trials and secured new strategic research funding to support development. By pairing robust science with practical scalability, FluGen continues to push toward a broader, longer-lasting defense against infectious disease.

Top Companies to Watch in Milwaukee

Rockwell Automation

Rockwell Automation creates industrial hardware, software, and AI-driven systems that modernize manufacturing. In 2025, the company opened a Smart Manufacturing Center in Milwaukee and expanded its FactoryTalk analytics platform to support real-time decision-making. Its focus on connected operations is powering the next industrial evolution.

Northwestern Mutual

Northwestern Mutual provides life insurance and financial planning services to millions of clients, so they can make their money work for them. In 2025, it introduced a digital-advisor platform tailored for younger investors and committed over $100 million to fintech and insurtech ventures. Its embrace of technology and inclusive wealth-building reflects a modern approach to financial security.

Badger Meter

Badger Meter designs intelligent water-measurement and analytics systems that help utilities conserve resources and improve service. The 2025 launch of its Orion Gateway platform expanded real-time monitoring and secured major new municipal contracts. These capabilities position Badger Meter as a key player in building smarter, more sustainable cities.

Regal Rexnord

Regal Rexnord produces motion-control and power-transmission systems that drive industrial performance. It invested 400 million dollars this year in automation projects and opened a digital manufacturing hub in Wisconsin. By pairing engineering heritage with digital innovation, the company is advancing how industrial systems move, connect, and conserve energy.

Johnson Controls

Johnson Controls designs smart-building systems that integrate HVAC, fire safety, and energy management. Its 2025 acquisition of a building analytics firm strengthened the OpenBlue platform and introduced subscription-based services that optimize performance over time. The company’s focus on efficiency and intelligence continues to define the modern built environment.

Zurn Elkay Water Solutions

Zurn Elkay develops water safety and hygiene systems for commercial and institutional spaces. In 2025, it introduced antimicrobial plumbing fixtures and signed a multi-year supply deal with a major healthcare chain. Its focus on water purity and safety highlights how industrial design can directly support public health.

Clarios

Clarios manufactures advanced automotive and energy-storage batteries that power over 140 million vehicles annually. The company launched an EV-specific product line in 2025 and expanded its North American recycling facilities. With closed-loop manufacturing and circular-economy principles, Clarios is shaping the sustainable energy supply chain.

Komatsu Mining

Komatsu Mining produces electric and autonomous equipment for the global mining industry. In 2025, it debuted a battery-electric haul truck and expanded its Wisconsin service center to support decarbonized fleets. The company’s engineering breakthroughs are redefining what productivity looks like in heavy industry.

A. O. Smith

Direct Supply

Direct Supply provides equipment, technology, and logistics solutions for senior-living and healthcare providers. The company launched its Connected Living IoT platform in 2025 and pledged $50 million toward workforce-development programs. Its focus on operational excellence and aging innovation continues to shape care environments nationwide.

HellermannTyton

HellermannTyton designs connectivity and cable management systems used across industrial, data center, and automotive markets. In 2025, it introduced a high-density tray system and opened a new application lab in Milwaukee. The expansion strengthens Wisconsin’s role in advanced manufacturing and product engineering.

Wantable

Wantable curates personalized apparel and activewear through a subscription model. In 2025, the company upgraded its AI-styling engine and deepened partnerships with emerging fashion brands. Its combination of technology and local craftsmanship keeps Wisconsin’s retail creativity in the national spotlight.